ea0041gp111 | Endocrine Tumours | ECE2016
Vitali Eleonora
, Ferrero Stefano
, Peverelli Erika
, Veronesi Giulia
, Alloisio Marco
, Santambrogio Luigi
, Spada Anna
, Mantovani Giovanna
, Lania Andrea
Pulmonary neuroendocrine tumors (PNTs) comprise a spectrum of neoplasms, ranging from low grade carcinoids to the highly malignant small cell lung cancers. Several studies identified cytoskeleton protein Filamin A (FLNA) as determinant in cancer progression and metastasis. To date, the role of FLNA in PNTs aggressiveness and progression is still unknown.To address this question, we decided: i) to evaluate FLNA expression in PNTs ranging from typical carc...